Jurgen Klopp’s team found themselves paired against the Premier League side for a third time in four seasons, having lost 1-0 at Signal Iduna Park last term and shared a 1-1 draw in 2011.
But Arsenal had no answer to waves of furious, pacey attacks from the Bundesliga outfit, who scored either side of half-time through impressive attacking duo Ciro Immobile and Pierre-Emerick Aubameyang.
Italy international Immobile netted his first goal since joined Dortmund from Torino with a superb solo effort, while Aubameyang’s display of speed and incision punished Arsene Wenger’s men again in the 48th minute.
Tellingly, Arsenal striker Danny Welbeck passed up good chances shortly before both Dortmund goals but the scoreline was ultimately flattering to the England international and his team-mates.
Former Manchester United playmaker Shinji Kagawa started on the bench following a goalscoring return to Dortmund colours against Frieburg on Saturday, while Sven Bender made his first appearance in midfield since February having recovered from a thigh injury.
Arsenal’s defensive shortage was well documented before kick-off and, with Calum Chambers only among the substitutes due to a bout of tonsillitis, 19-year-old Hector Bellerin made a debut at right-back.
Juventus 2 – 0 Malmo FF
Olympiakos 3 – 2 Atletico Madrid
Liverpool 2 – 1 PFC Ludogorets Razgrad
Real Madrid 5 – 1 Basel
Benfica 0 – 2 Zenit St. Petersburg
Monaco 1 – 0 Bayer Leverkusen
Borussia Dortmund 2 – 0 Arsenal
Galatasaray 1 – 1 Anderlecht