Arsenal are likely to be without Mesut Ozil when they face Manchester United on Wednesday, while Granit Xhaka is suspended.
The German playmaker sat out last Sunday’s 4-2 north London derby win over Tottenham and reports emerging from the Gunners camp ahead of the trip to Old Trafford are that he will not be risked against United by head coach Unai Emery.
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The Spanish tactician will also be without Xhaka after he collected his fifth booking of the season at the weekend, meaning one of Aaron Ramsey, Mohamed Elneny or Matteo Guendouzi will come into the Arsenal midfield.
The Londoners will make a check on the fitness of left-back Nacho Monreal ahead of kick-off as he battles to overcome a hamstring injury, but he is unlikely to make it.
Emery may opt to freshen up his starting line-up after the exertions of the derby, with Alexandre Lacazette starting on the bench against Tottenham.
Meanwhile, concerns over the fitness of defender Laurent Koscielny have been played down after the Frenchman limped out of Arsenal Under-23 loss to Portsmouth in the Checkatrade Trophy on Tuesday.
Youth coach Freddie Ljungberg says Koscielny, who hasn’t featured for the first team since May after rupturing his Achilles, was suffering with cramp in the latter stages of the clash.