Tottenham boss Mauricio Pochettino will have to shuffle his pack with a number of players out for the arrival of Barcelona on Wednesday.
Spurs host the La Liga title holders looking to kick-start their Champions League campaign following defeat at Inter Milan in the opening group match last month.
The north Londoners will fancy their chances as Barca have wobbled domestically lately with two draws and a defeat, to bottom side Leganes, in their last three matches.
However, Spurs will have to do it without regulars Christian Eriksen, Mousa Dembele and Jan Vertonghen, who have joined Dele Alli on a growing casualty list at the club.
Manager Mauricio Pochettino said: “It is a period when we are not having good luck with injuries.
“We are not victims though. We must feel strong. Every player must feel they can win and achieve what we want.”
Spurs are, though, boosted by the return of keeper and skipper Hugo Lloris, who returns in goal after recovering from a thigh injury.