Wilfred Ndidi was in action for Leicester who lost 3-0 away to Manchester United at Old Trafford in Sunday’s Premier League game.
Ndidi and his Leicester teammates have now lost three of their last four games. The Super Eagles’ midfielder was replaced on 70 minutes.
Van Nistelrooy was able to hand over the reins with a four-game unbeaten run since stepping up to replace the sacked Erik ten Hag.
Bruno Fernandes marked his 250th United appearance by smashing in his fourth goal in four games after a neat interchange of passes with Amad Diallo.
Fernandes’ burst into the box also created the second goal as his glancing touch deflected off Leicester defender Victor Kristiansen and in for an own goal.
Diallo’s two-goal showing in a 2-0 Europa League win over PAOK on Thursday earned the Ivorian a start over Alejandro Garnacho.
The Argentine, though, came off the bench to show what he is capable of with a stunning strike into the top corner to round off the scoring.
United remain down in 13th but are now just three points off fifth while Leicester is in 15th place in the table.
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