Marouane Fellaini, Fred and Diogo Dalot are in line to return to Manchester United XI for the FA Cup third-round visit of Reading.
All three have been nursing knocks but could be given a chance to impress by Ole Gunnar Solskjaer, with The Red Devils looking to continue their perfect winning start under the Norwegian manager.
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Goalkeeper Sergio Romero could also make his first start ahead of David de Gea since back in September for the visit of the struggling Championship club.
Alexis Sanchez returned from injury to feature off the bench against Newcastle United on Wednesday and the Chilean forward could be given a starting role against the Royals to build up his fitness.